Paper Information

Title: 

EFFECT OF SHALLOT AND GARLIC EXTRACT ON LEARNING AND MEMORY IN FRUCTOSE-INDUCED INSULIN RESISTANT RATS

Type: POSTER
Author(s): BAGHERI SEYED MAJID,JALAL R.,MOGHIMI ALI
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Insulin resistance is defined as the reduced response of cells to the physiological levels of insulin. The level of glycosylation and oxidative stress has been increased in the insulin resistance state. It has been shown that insulin resistance is associated with an increased relative risk for some of neurodegenerative disorders such as Alzheimer's disease (AD). The previous studies have been shown that antioxidant agents can improve the memory in diabetic rats. Shallot and garlic have antioxidant effects. In this study, we investigated the effect of shallot and garlic on spatial memory in insulin resistant rats.
Methods: Insulin resistance induced by high-fructose diet for a period of eight weeks. Fructose-induced insulin resistance rats were treated by aqueous shallot or garlic extracts (500 mg/Kg BW/day, i.p.) for duration of twelve weeks. Control groups (positive and negative) received normal saline. To examine memory/learning ability, the animals were subjected to the Morris water maze. For this purpose, the rats were trained for 5 consecutive days (4 trial everyday). Rats were allowed to find the hidden platform during 60 s and permitted to stay on it for 30 s. If the rat did not find the platform within 60 s, it was placed on the platform for 30s.
Results: Memory of insulin resistant rats (sham group) was significantly decreased compare to the control group (negative group). The memory of the animals that received shallot and garlic extract improved numerically but it was not statistically significant.
Conclusion: Our results indicated that insulin resistance can have adverse effect on the spatial memory and shallot and garlic might be useful to moderate this adverse effect.

 
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