Paper Information

Title: 

RELAXANT EFFECT OF CROCUS SATIVUS (SAFFRON) ON GUINEA PIG TRACHEAL CHAINS AND ITS POSSIBLE MECHANISM (S)

Type: POSTER
Author(s): ASLANI M.R.*,BOSKABADI M.H.
 
 *DEPT OF PHYSIOLOG, GHAEM MEDICAL CENTRE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Therapeutic effect of Crocus sativus on respiratory diseases is indicated in Iranian ancient Medical books. Therefore, the relaxant effects of Crocus sativus on tracheal chains of guinea pigs were examined.
Methods: The relaxant effects of 4 cumulative concentrations of aqueous-ethanolic extract in comparison with saline as negative control and 4 cumulative concentrations of theophylline as positive control were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 10 µM methacholine (group 1) and 60 mM KCl (group 2), (n=6).
Results: In groups 1 and 2 all concentrations of theophilline, extract and safranal showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). There were significant correlations between the concentrations of the extract and theophylline with their relaxant effect in both groups (p<0.001 for al cases).
Conclusion: These results showed a potent relaxant effect of
Crocus sativus on tracheal chains of guinea pigs that was comparable than that of theophylline.

 
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