Paper Information

Title: 

POSSIBLE MECHANISN FOR THE RELAXANT EFFECTS OF DIFFERENT FRACTIONS FROM ROSA DAMASCENA ON GUINEA PIG TRACHEAL CHAINS AND ITS POSSIBLE MECHANISM (S)

Type: POSTER
Author(s): TABEEI T.*,BOSKABADI M.H.,RAKHSHANDEH H.,MOUSAVI Z.,GHOLAMI M.
 
 *DEPT. OF PHYSIOLOGY, MUMS, MASHHAD
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Several therapeutic effects have been described for the flowers of Rosa damascena. Therefore in the present study, the relaxant effects of aqueous, ethyl acetate and N-butanol fractions of Rosa damascena on tracheal chains of guinea pigs were examined.
Methods: The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline as negative control and three cumulative concentrations of theophylline (0.1, 0.2, and 0.4 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n=5) and 10 µM methacholine (group 2, n=8).
Results: In groups 1 experiments all concentrations of theophylline, aqueous, ethyl acetate and two final concentrations of N-butanol fractions showed significant relaxant effects compared to that of saline (p<0.01 to p<0.001). In group 2, all concentrations of theophylline, ethyl acetate and aqueous fractions showed concentration dependent relaxant effects compared to that of saline (p<0.01 to p<0.001). However, N-buthanol fraction did not show any sibnificant relaxant effect on tracheal chains in this group. In addition, the effect of ethyl acetate fraction in group 1 was significantly higher than theophylline in both groups (p<0.01 to p<0.001).
Conclusions: These results showed a potent relaxant effect of different fractions from
Rosa damascena on tracheal chains of guinea pigs. The results suggest a muscarinc antagonistic effect for aqueous and acetyl acetate fractions and an inhibitory effect of ethyl acetate and n-butanol fractions on calcium channels.

 
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