Paper Information

Title: 

INTERACTION OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID ON BLOOD GLUCOSE, LFT AND LIPID METABOLISM IN DIABETIC MALE RAT

Type: POSTER
Author(s): JADID ALESLAMI M.*,ABBASNEZHAD M.,SHAHRAKI M.R.
 
 *DEPARTMENT OF BIOLOGY, KERMAN SHAHID BAHONAR UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Aloe vera is a native to north of Africa and also cultivated in Turkey. Aloes have long been used all over the world for their various medicinal properties. The aim of this study is to survey the interaction of Aloe vera and glibenclamid on blood glucose, LFT and lipid metabolism in streptozotocine-induced diabetic male rats.
Methods: This survey was carried out on 40 male rats. Animals are divided into one control and four test groups. Tests groups were made diabetic by streptozotocin (65mg/ kg-IP). Blood samples were collected from all groups, for FBS test after a week. Then 2 to 4 test groups received 400mg/kg Aloe vera extract, 5mg/kg glibenclamid and 400mg/kg Aloe vera extract with 5mg/kg glibenclamid daily for 4 weeks by gavages, respectively. At least fasting blood samples were collected from all groups.
Results: The results showed that FBS, TG, Ch, AST, ALT levels in 3-5 groups significantly decreased compared with those of test control group (P<0.05), but HDL level remained without any change. In addition Alk.P level in 4 and 5 groups significantly increased compared with control group.
Conclusion: The results of this research indicate that effect interaction of Aloe vera aqueous extract and glibenclamid was not greater than the effect of Aloe vera extract alone. This effects may be due to the effect of Aloe vera and glibenclamid on glucose metabolism hence; further next study is suggested for exact mechanism of them in diabetic rats.

 
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