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Paper Information

Title: 

INVOLVEMENT OF OPIOIDERGIC AND SERTONERGIC SYSTEMS IN ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM

Type: POSTER
Author(s): FEREYDOUNI M.,ETEMADI L.*,POURHAMID D.
 
 *DEPT OF BIOLOGY, AZAD UNI. OF DAMGHAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Fever few (Tanacetum parthenium) (T.p) is widely used in folk medicine for treatment of many diseases. Present study was designed to find the systems which involve in the anti-nociceptive effect of the aqueous extract of T.p flower.
Method: Based on our previous study, the dose 50 mg/kg i.p of the T.p aqueous extract had a potent analgesic effect on mice (NMRI) (20 ± 2 gr) in formalin test which are used in this study also. Here we study the rules of opioidergic, sertonergic, a-andrenergic and nitric oxide (No) systems on anti-nociceptive effect of the extract. Before the extract treatments, animals had pretreated with opioid antagonist naloxone (5mg/kg, i.p), sertonergic antagonist syproheptadyene (4 mg/kg, i.p),
a-adrenergic antagonist phentolamine (20 mg/kg, i.p) and No precursor L -arginine (600 mg/kg,i.p) separately (each group with n=6). Saline and extract used as control.
Result: In comparison with extract analgesic effect, pretreatment with naloxone increased the pain sensation in neurogenic phase of formalin test (p<0.001). Pretreatment with syproheptadyene increased the sensation of pain in both early and late phases (p<0.05). Inhibition of
a-adrenergic and No system were not able to decrease the anti-nociceptive effect of the extract.
Conclusion: The involvement of sertonergic system in anti-nociceptive effect of the T.p extract is proposed by the results. Also the involvement of opioidergic system has to be mentioned in this effect.

 
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