Paper Information

Title: 

PROTECTIVE EFFECTS OF NATURAL HONEY ON REPERFUSION-INDUCED ARRHYTHMIAS IN SHORT-TERM APPLICATION

Type: POSTER
Author(s): RAFI F.,NAJAFI M.,MAHDIZADEH AGHDAM E.,ETERAF OSKOUEI T.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In this study, prophylactic effects of natural honey on reperfusion-induced cardiac arrhythmias were investigated in isolated rat hearts.
Methods: Isolated rat hearts were divided into three groups (n=8 in each group) and mounted on a Langendorff apparatus at constant pressure. In the control group, the hearts were perfused by a modified Krebs-Henseleit solution during stabilization, 30min regional ischemia followed by 30min reperfusion however, in the test groups, they were perfused by enriched Krebs solution with natural honey (0.5 and 1%) 10min before to 10min after ischemia. Then the reperfusion-induced cardiac arrhythmias were analyzed based on the Lambeth conventions.
Results: The total number of ventricular ectopic beats (VEBs) in the control group was 349±73 while perfusion of (natural honey 0.5 and 1%) reduced it to 149±95 (P<0.05) and 145±25 (P<0.01) respectively. The number of ventricular tachycardia (VT) was also lowered by the same concentrations from 154±29 (control) to 71±30 and 51±24 (P<0.05) respectively. In addition, honey (0.5%) decreased the incidence of VT in comparison with the control group (P<0.05). Statistical comparison between the test groups did not show significant difference in antiarrhythmic effects of honey.
Conclusion: This study showed a protective effect for natural honey against reperfusion injuries in isolated rat hearts. It seems in this antiarrhythmic action, the presence of antioxidant compounds (such as phenolic and organic nonaromatic acids) may involve.

 
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