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Paper Information

Title: 

EFFECT OF AQUEOUS-ETHANOLIC EXTRACT FROM CROCUS SATIVUS (SAFFRON) ON GUINEA PIG ISOLATED HEART

Type: POSTER
Author(s): SHAFEI M.N.,BOSKABADI M.H.,SHAKIBA A.,SANG SEFIDI H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Several therapeutic effects have been described for the seeds of Crocus sativus. In the present study, the effects of aqueous-ethanolic extract from Crocus sativus on heart rate and contractility of isolated heart were examined.
METHDS: Isolated guinea-pig hearts were perfused through aorta in a Langendorff mode. Heart rate (HR) and contractility were determined in the presence
of four concentrations of aqueous-ethanolic extract from Crocus sativus (0.1, 0.5, 1.0 and 5.0 mg%) and diltiazem, a calcium channel blocker (0.1, 1, 10 and 100 µM) in comparison with baseline values in two different groups of experiments as follows:  1) Perfused heart with ordinary Krebs solution (group1 experiments, n=9). 2) Perfused heart with calcium free Krebs solution (group 2 experiments, n=7).
RESULTS: In group 1, three higher concentrations of diltiazem showed significant reduction in heart rate and heart contractility (p<0.05 to P<0.001). However, in this group, only highest and two larger concentrations of the extract caused significant reduction in heart rate and heart contractility respectively (p<0.05 to P<0.01). In group 2, highest and 2 last concentrations of diltiazem showed significant reduction in heart rate and heart contractility respectively (p<0.05 to p<0.01). In addition only last concentration of the extract from Crocus sativus showed significant nreduction in both heart rate and heart contractility (p<0.05 to p<0.01). There were significant negative correlation between concentrations of the extract and diltiazem and their effect on heart rate and contractility in both groups (p<0.01 to p<0.001).
CONCLUSIONS: These results suggested a potent inhibitory effect of aqueous-ethanolic extract from Crocus sativus on calcium channel of guinea pig heart that was comparable to that of diltazem.

 
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