Paper Information

Title:  THE STUDY OF GARLIC EFFECTS ON HYPERTENSION IN THE GOLDBLATT'S RATS MODEL
Type: POSTER
Author(s): VAHIDINIA A.A.,ZAREI M.*,HESHMATIAN B.,SALEHI IRAJ
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The renin angiotensin system has an important role in the hypertension. The garlic effects on hypertension had been known. The aim of the present study was to determine interaction between garlic effects on hypertension in the Goldblatt' rats model.
Methods: Four groups of normotensive Wistar rats were selected for this study. In half of rats were induced hypertension by Goldblatt method and others were subjected with a sham procedure. After six weeks, tests were performed on rats. One group of the Goldblatt's rats and one group of the sham's rats were selected, in both of them during one month were done with garlic gavage (600 mg) daily. The direct measurements of the femoral blood pressure were recorded and mean arterial pressure changes compared between groups.
Results: Our results showed that the mean arterial pressure has change but there is no significant difference in mean arterial pressure between groups of with garlic and without it.
Conclusion: This study concludes that garlic effects direction is differ from renin angiotensin system probably.

 
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