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Paper Information

Title: 

EFFECT OF ACETAMINOPHEN IN CARDIOPLEGIC SOLUTION ON ISOLATED RAT HEART

Type: POSTER
Author(s): SHAKIBAEI D.*,DAVARI M.,GODINI A.L.
 
 *DEPARTMENT OF PHYSIOLOGY AND MEDICAL BIOLOGY RESEARCH CENTER, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Cardio protective effect of acetaminophen has been shown in recent investigations. The purpose of this study was to examine the effect of acetaminophen in cardioplegic solution on isolated rat heart function.
Methods: Wistar male rats (n=7/group) were used in this experiment. Hearts of animals were isolated according langendorff method and perfused by Krebs solution under constant pressure. Experimental protocol was Ι. Stabilization period and recording of baseline values (30min). ΙΙ. Cardioplegia (60min) and ΙΙΙ. Repefusion (45min).In addition to this protocol, acetaminophen (0.35 mmol/lit) was added to Krebs solution for 10 min before and during cardioplegia in test group. Cardiac function parameters (left ventricular pressure and heart rate) and coronary flow were measured during different experimental periods and the means of parameters were compared among groups with using of unpaired t tes.
Results: Results showed that in the first period there weren't significant differences in left ventricular pressure and coronary flow (12.78±0.9 and 13.92±1.41 ml/min) in control and test groups respectively. However after cardioplegia followed by 45 min reperfusion there weren't any significant differences in functional recovery percentage of control and test hearts (46.3±3.63 and 45.4±5.58) respectively. Meanwhile coronary flow in test group significantly increased in comparison to control (6.78±0.35 and 8.74±0.83 ml/min).
Conclusion: In summary results showed the better coronary flow preservation after cardioplegia in test group. This result shows new evidence about the cardio protective effect of acetaminophen in heart that probably is due to phenolic structure and antioxidant nature of the drug.

 
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