Paper Information

Title: 

CARDIOVASCULAR EFFECTS OF 3 NEW SYNTHETIC CALCIUM CHANNEL BLOCKERS IN RABIT

Type: POSTER
Author(s): RAHMANI SH.,NAJAFIPOUR H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: nifedipine is used in the treatment of hypertension. We investigated the effects of 3 newly synthetized ester analogs of nifedipine on mean arterial pressure, cardiac contractility index (dp/dt) and heart rate.
Materials and Methods: Rabbits were anaesthetized with diazepam and sodium pentobarbital. The right femoral vein and artery were cannulated for injections (phenylephrin and sodium pentobarbital) and record of arterial blood pressure respectively. Right jugular vein for injection of synthetic compounds. Another cannula was inserted in carotid artery and pushed to leave ventricle to record the left ventricular dp/dt. Then the new compounds were tested in two stages. In the first stage in normotensive conditions, 1ml nifedipine (10-3M) and five minutes later 1ml of one of the new compounds were injected and their effect on arterial blood pressure and left ventricular dp/dt was recorded. In the second stage, arterial blood pressure was increased by 20 mmHg and then the first stage experiments were repeated in hypertensive conditions.
Results: In hypertensive conditions, 10-3M of nifedipine reduced the MAP and dp/dt by 22.1%,and 19.7% respectively, and increased the HR by 4.8%. Compound 1 reduced MAP by 7.5%, and dp/dt by 8.3% but had no effect on HR. Compound 2,reduced MAP, and dp/dt by 9% and 11.2% respectively, but had no effect on HR. Compound 3 decreased 10.2% MAP, and 7.6% dp/dt and increased HR by 1.4%. Compounds 1 and 2 significantly reduced heart rate compared with nifedipine (p<0.05).
Conclusion: compound 2 is closer to nifedipine in reducing MAP and dp/dt, but does not increase HR. It may be selected for further investigation to increase its antihypertensive effect. Then it may be used in hypertensive patients with IHD as it does not increase HR and O2 consumption.

 
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