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Paper Information

Title: 

TESTS, HISTORICAL EFFORTS AND IMMUNE RECONSTITUTION CORD BLOOD STEM CELLS TRANSPLANTATION

Type: POSTER
Author(s): ALIZADEH SHABAN,ABEDI ALI,BOHLOULI SH.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Allogeneic stem cell transplantation is an accepted treatment modality for selected malignant and non-malignant diseases. However, the ability to identify suitably matched related or unrelated donors can be difficult in some patients. Alternative sources of stem cells such as cord blood provide a readily available graft for such patients. Since the cell numbers of hematopoietic progenitors in cord blood is limited and the collection can occur only in a single occasion, its use in adult patients can be more problematic.The patient outcomes should be review and analyze for various factors such as cell dose, HLA typing, and patient selection that could have contribute to the final outcome of these adult patients. Discussion of the various benefits and risks should be present. Description of the historical efforts associated with expansion of hematopoietic stem cells, specifically with cord blood cells expand cord blood cells continue with novel methods. Moreover, a better understanding of stem cell biology and signaling is critical if we are to be able to effectively expand these cells for clinical use. Describe the immune reconstitution or lack thereof following cord blood transplantation appears be very important, one of the hallmarks of successful hematopoietic stem cell transplantation is the ability to fully reconstitute the immune system of the recipient. Thus, the relationship between stem cell source and the development of T lymphocyte functions required for protection of the recipient from infection will be described, and cord blood recipients will be compared with those receiving other sources of stem cells.

 
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