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Paper Information

Title: 

THE EFFECT OF SUBCUTANEOUS INJECTION OF MORPHINE ON BLOOD PRESSURE AND BODY TEMPERATURE OF MORPHINE DEPENDENT

Type: POSTER
Author(s): SAFARI F.*,HAJIZADEH S.,FATH ELAHI Y.,AZIZI H.
 
 *DEPT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Morphine has been found to influence body function such as changes in blood pressure and body temperature. In other hand evidences show that morphine dependency changes tissue sensitivity to acute dose of morphine. Therefore, in this study we investigated the effect of subcutaneous injection of morphine on blood pressure and body temperature in dependent rats compare to the intact rats.
Methods: Rectal temperature and tail blood pressure were measured. Induction of morphine dependency was performed by oral standard protocol.
Results: The results show that subcutaneous injection of morphine (3mg/kg) increased body temperature of dependent rats by 1/1 and in intact rats by 1/4.Whereas the amount of increase was significant in both of groups and remained unchanged to the end of the experiment (70 minutes), but there was no significant difference between intact and dependent groups. Blood pressure of dependent rats was decreased 24 minutes after morphine injection (3mg/kg, S.C) by 17.9%. In intact rats 20 min. after morphine injection, blood pressure was decreased by 18.6%. Decrease of blood pressure continued until the end of the experiment. The percentage of decrease of blood pressure in morphine dependent rats was not different to intact group.
Conclusion: Based on these results it could be concluded that subcutaneous injection of morphine causes hypotension and hyperthermia in dependent rats as same as to the intact group.

 
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