Paper Information

Title: 

THE EFFECT OF L-CARNITINE ON BLOOD PRESSURE REGULATORY MECHANISMS IN STZ-INDUCED DIABETIC RATS

Type: POSTER
Author(s): SHARIFI A.M.,GHADERPANAHI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Diabetes mellitus is a major public health problem and Hyperglyceamia can lead to hypertension in long-standing diabetes that increases risk for developing cardiovascular diseases. There is evidence of possitive effects of L-carnitne on hypertension. In peresent study, the possible effect of L-carnitne on nitric oxide (NOx) level, angiotencin-converting enzyme (ACE) activity and systolic blood pressure (SBP) in STZ - induced diabetic and healthy rats were investigated.
Methods: Rats were divided to four groups as non-treated control(C), L-carnitne treated control (CT), diabetic (D) and L-carnitne treated diabetic (DT). Rats were induceded diabetes by stereptozotosin. During 12 weeks study, L-carnitne treated groups were recieved 250 mg/kg/day L-carnitne in drinking water and C & D groups were had a free availability to food and water. At the end of study, SBP, NOx and ACE activities were measured.
Results: In L-carnitne treated diabetic group (DT), systolic blood pressure was significantly decreased compared to diabetic group (D). Serum ACE activity was also significantly decreased in DT group compared to D group. The serum NOx was significantly increased in DT & CT groups compared to D & C groups respectively.
Conclusion: On the basis of these results, it could be concluded that
L-carnitine may reduce SBP in diabetic rats via increasing nitric oxide level and decreasing in angiotencin converting enzyme level.

 
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