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Paper Information

Title: 

THE EFFECT OF CRATAGUS OXYCANTA ON THE BASIC AND FUNCTIONAL ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED PERFUSED RABBIT AV-NODAL PREPARATION

Type: POSTER
Author(s): SAFARI F.,KHOURI V.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background & Objective: Herbal remedies are suitable alternatives for synthetic drugs. Pharmacological studies and Traditional medical literature point to the cardiovascular effects of the cratagus.o. (Iridaceae) in many instances; the aim of the present study was to determine the electrophysiology base effect of the hydroalcohlic extract of cratagus .o. on an isolated AV node. Also we determined effect of plant on concealment zone. Methods: this is a experimental study. We used isolated per fused rabbit AV-nodal preparation in two groups. In the first group, the control group, we studied the electrophysiological properties of AV-node. In the second group, the effect of cratagus hydroalcholic extract was tested in the presence of extract (0.1,1,3 mg/l) and repeat.we used 8 rabbits in two groups. Statistical analysis was performed by SPSS Mean wasused in the all results.
Results: our results showed that cratagous.o. at concentration of 3 mg/L increased FRP from 173±1/8 control to 180±3/6. The concealment zone has unaffected by all concentrations of cratagus.o.
Conclusion: our results showed the minor role of this plant on the AV node changed by cratagus.o. but concealment zone Unaffected by the plant. All above results indicated that cratagus.o. (0.6 - 3mg/L) has limited antiarhythmic properties.

 
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