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Paper Information

Title: 

RELATION BETWEEN REGULAR SWIMMING AND OXIDATIVE STRESS IN HIPPOCAMPUS OF DIABETIC MALE RATS

Type: POSTER
Author(s): SALEHI IRAJ*,MOHAMMADI MOSTAFA,FARAJNIA S.A.,NAGINAGHADEH A.
 
 *TABRIZ UNIVERSITY OF MEDICAL SCIENCES, DRUG APPLIED RESEARCH CENTER
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Diabetes is a metabolic disorder that produced by low secretion of insulin or resistant to insulin. Oxidative stress is an imbalance between the free radical production and antioxidant defense systems of the body and strongly related with diabetes and symptoms of it. Swimming exercise via enhancing antioxidant defenses can decrease the symptoms of diabetes.
Methods: Diabetes was produced by streptozotocin (STZ, i.p injection, single dose, 50mg/Kg). Duration of exercise was 8 weeks. At the end of experiments, the rats were anesthetized by ether and the heads cut by guillotine, brain removed and hippocampus of brain was removed on ice immediately. Tissue was homogenized in prepared buffer and after sentrifusion produced supernatant was used for determination of SOD, GPX and CAT activities, and MDA level.
Results: Diabetes reduced SOD activity and GPX of hippocampus in diabetic rats significantly. MDA level increased in diabetic rats significantly compared with control. In response to exercise MDA level decreased in diabetic rats and SOD activity, GPX and catalase activity increased significantly.
Conclusion: Swimming exercise by increasing of hippocampus antioxidant enzymes and decreasing of MDA level has beneficial effects in prevention the neurotic symptoms of diabetes mellitus and tissue injuries by oxidative stress produced by this disease.

 
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