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Paper Information

Title: 

THE EFFECT OF VERJUICE ON ATHEROSCLEROSIS IN MICE

Type: POSTER
Author(s): SHARIFIRAD T.,HAJZADEH M.A.R.,MOGHIMI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Atherosclerosis is one of the major causes of death in human communities, both in industrial and underdeveloped countries. The early prevention and treatment of atherosclerosis reduce the risk of myocardial infarction and stroke. Different methods of treatment such as statin and synthetic drug therapy or other invasive methods have been used to remove atherosclerotic plaque. Herbal medicine products have been widely used for treatment of diseases show useful effects with less side effects. The aim of this study was to investigate the effects of verjuice solution on atherosclerotic plaque and serum lipids in a mouse model. The animals were divided into 6 groups. Group A (intact control) was received normal diet; Groups B(negative control) and C, D, E, F (experimental) all were fed with 2% cholesterol in diet. Groups C (preventive) and D (treatment) were further treated 7ml/kg/day verjuice solution in drinking water respectively from the first and the 42ed days throughout the experiment. Groups E (preventive) and F (treatment) were treated with14ml/kg/day of verjuice solution in the same way as C and D. At the end of study(12 weeks) blood were collected and serum lipids were measured by routine laboratory enzymatic techniques; the hearts and aorta were removed and parts of aorta was examined for the presence of atherosclerotic plaque with the routine histhological methods. The data demonstrated that the differences between groups were insignificant. The results also demonstrate that 2% cholestrol regimen was not able to induce atherosclerotic plaque in cholesterol fed mice. Therefore; it may be concluded that this animal model is not a proper one for the study of atherosclerosis and other animal models such as rabbit are recommended. 

 
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