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Paper Information

Title: 

EFFECT OF SHORT-TERM AND SUBCHRONIC LEAD EXPOSURE ON ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN RAT

Type: POSTER
Author(s): HEYDARI A.*,NOROUZZADEH A.,KHOUSHBATEN A.,ASGARI A.
 
 *DEPT. OF PHYSIOLOGY AND PHARMACOLOGY, MEDICAL FACULTY, KASHAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Exposure to low levels of lead can induce hypertension in humans and experimental animals. The exact mechanisms of lead-induced hypertension are unclear and change in vascular reactivity, nitric oxide and rennin-angionensin system may be involved. In current study, we examined the effects of short term (4-8 weeks) and chronic (12 weeks) lead exposure on blood pressure and serum angiotensin converting enzyme activity.
Methods: Male Sprague-Dawley rats (180-220 gr) were exposed to 100 ppm lead acetate in drinking water for 12 weeks. Blood pressure was monitored every week using rat tail sphygmomanometer (PE 300, Narco Biosystems) and serum angiotensin converting enzyme activity was measured with spectrophotometric assay after extracting hippurate from Hippuryl-L-Histidyl-L-Leucine (HHL).
Results: Systolic blood pressure significantly increased at the end of short term (p<0.05) and subchronic stage (p<0.01) of lead exposure. The activity of serum angiotensin converting enzyme activity was reduced at the end of short term (p<0.05) and subchronic stage (p<0.01) of lead exposure.
Conclusion: Our results confirm that lead enhances blood pressure even in the early stages of exposure. The reduced angiotensin converting enzyme activity may be secondary to elevation of blood pressure. It seems that renin- angiotensin system has no role in development of lead-induced hypertension and other pathways may be involved.

 
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