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Paper Information

Title: 

THE EFFECT OF VIT E ON QT INTERVAL IN DIABETIC RAT HEART

Type: POSTER
Author(s): BEHKAMI J.*,RASHIDI M.,EMAMI H.
 
 *DEP. OF PHYSIOLOGY, FACULTY OF MEDICINE, URMIA, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background The risk for cardiovascular disease is significantly high in diabetes Mellitus. Experimental evidence suggests that oxidative stress plays dominant role in the pathogenesis of diabetes mellitus. In this experiment we examined the effect of vit E as an antioxidant on QT interval on in diabetic rat heart.
Methods: Twinty-four male wistar rats were divided into three groups. Group І, control (nondiabetic) group II non treated diabetic rat and group III diabetic treated with 300 mg/kgBw vit E. After 6 week, the ECG was done on all rats.
Results The QT in intter wall amounts were 0/1937, 0/25 and 0/19 in group І, group П and group Ш respectively. QT interval showed significantly increase in nontreatal group compared control group (p<0/000). There were no difference in the QT inter wall between diabetic treated group and control group (p<0/1).
Conclusions: these results shown that the vit E prevent QT interval increasing induced by diabetes.

 
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