Paper Information

Title: 

INVESTIGATION ON THE RESPONSIVENESS OF BETA-2 ADRENOCEPTORS OF DIABETIC RAT KNEE JOINT BLOOD VESSELS IN ACUTE INFLAMMATION

Type: POSTER
Author(s): HAJIZADEH S.,ERFANI B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The aim of this study was to investigate the vasodilator response of knee joint blood vessels to salbutamol (Beta-2 adrenoceptor agonist) in insuline dependent diabetic rats in presence of acute inflammation. Acute knee joint inflammation was induced by intraarticular injection of kaolin 4% and induction of diabetes was performed by streptozotocine (55 mg/kg). Wistar rats weighting 200-300 gr. were used. The animals divided in 5 groups as: Control, saline, diabetic, inflammatory and diabetic- inflammatory. Blood flow of knee joint was measured using Laser Doppler Flowmetry Technique (LDF). Vasodilatation of articular microvascular was measured in response to topical application of different concentration (10 -11 -10 -1) of salbutamol. Results obtained showed that: 1- Increased knee joint diameter and perimeter due to acute inflammation in diabetic rat knee joint were significantly lesser than that of inflammatory rats. 2- Responsiveness of Beta-2 adrenoceptors was increased in kaolin- induced acute inflammation. 3- In diabetic rats, kaolin- induced acute inflammation could not increase the responsiveness of Beta-2 adrenoceptors. Based on above mentioned results, we conclude that diabetes inhibits the increasing effects of acute inflammation on responsiveness of Beta-2 adrenoceptors.

 
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