Paper Information

Title: 

EFFECT OF AMLODIPINE ON HISTOLOGICAL CHANGES IN ARTERIES OF AORTA, KIDNEY AND CAROTID IN RABBITS RECEIVING ATHEROGENIC DIET

Type: POSTER
Author(s): BADALZADEH R.,MIRZARI F.,MOHAMMADI MOSTAFA,RASHIDI BAHMAN,SALEHI IRAJ
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Since in atherosclerotic vessels, obvious and certain changes with abnormality in transferring of calcium ions are seen, some researchers suggested that calcium channel blockers can be effective in slow downing and improving the process of atherosclerosis.
Methods: 36 male Newsland white rabbits were divided into four groups: The normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. Results: In aorta artery in high-cholesterol diet diameter of internal layer was increased and cells due to accumulation of lipids are seen as white similar to yellow. Hypertrophy of endothelial cells, accumulation of lipids in endothelial layers with calcification in media indicates induction of athroma. With amlodipine consumption, decrement of athrotic injuries was observed.
Results: in carotid artery in high-cholesterol diet showing incidence of athroma. With amlodipine consumption decrement of athrotic injuries was observed. In kidney artery in high-cholesterol diet atherosclerotic changes was not observed.
Conclusion: Significant differences were observed among arteries of aorta, kidney and carotid in atherosclerosis. In the kidney artery, the groups of high-cholesterol diet and high-cholesterol diet plus amlodipine were not different histologically but in arteries of aorta and carotid, amlodipine consumption was effective in decrement of atherosclerosis process. This difference can be related to difference in structure of artery endothelial cells or different distribution of related receptors.

 
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