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Paper Information

Title: 

RELATIONSHIP BETWEEN BODY MASS INDEX, SERUM LIPID LEVELS, AND IN-VITRO SERUM LIPID OXIDIZABILITY IN HEALTHY SUBJECTS

Type: POSTER
Author(s): JALALI KHANABADI B.A.*,JAFARI B.
 
 *BIOCHEMISTRY DEPT., YAZD UNIVERSITY OF MEDICAL SCIENCES, YAZD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Obesity is a well-known risk factor for atherosclerosis and some other disorders. Recent studies showed that higher BMI is associated with enhanced lipid peroxidation. The aim of this study was to assess the relationship between BMI, plasma lipid levels and lipid oxidizability parameters in a group of healthy subjects.
Methods: A total of 86 healthy volunteers (48 females, 38 males), were assigned to one of three groups according to their BMI, normal (BMI=22.2 +/- 1.97 Kg/m2, n=32), overweight (BMI=27.7 +/- 4.5 Kg/m2, n=32), and obese (BMI=33.25 +/- 2.4 Kg/m2, n=24). Fasting serum levels of cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and triglycerides were measured in three groups. Lipid oxidizability parameters were evaluated after Cu -induced lipid oxidation in diluted serum. Oxidation parameters including lag-time, maximal rate of oxidation (V-max), time of maximal rate of oxidation (T-max), and maximal amount of lipid peroxide products (O-D-max) were determined.
Findings: Serum levels of TC and LDL-C in obese (202 +/- 45 and 128.5 +/- 37 mg/dl) and overweight subjects (190 +/- 40 and 117 +/- 32 mg/dl) were significantly higher than normal subjects (170 +/- 32 and 98 +/- 26.5 mg /dl, p=0.04 and p= 0.02). From oxidizability parameters, only T-max was significantly (p=0.027) higher in obese (195 +/- 21 min) than normal (160 +/- 33 min) group. In all of subjects BMI correlate significantly with TC (r=0.4, p=0.001), LDL-C (r=0.4, p=0.001) and T-max (r=0.43, p=0.025).
Conclusion: The results of this study suggested that in the healthy subjects, there was a significant relationship between BMI and cholesterol-rich serum lipoprotein. BMI did not notable effect on serum lipids susceptibility to peroxidation.

 
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