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Paper Information

Title: 

EFFECT OF HYDROALCHOLIC EXTRACT OF FRUITS OF CRATAGUS-OXYCANTA ON THE RATE-DEPENDENT PROPERTIES OF RABBIT ATRIOVENTRICULAR ISOLATED HEART

Type: POSTER
Author(s): HOSSEINI SEYEDEH ATEFEH*,KHORI V.
 
 *GOLESTAN CARDIOVASCULAR RESEARCH CENTER, GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, GORGAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: pharmacological studies and traditional medical literature point to the cardiovascular effects of the cratagus. oxycanta (Iridaceae) in many instances. The aim of the present study was to determined role of hydroalcholic extract of cratagus on the functional properties of AV-node.
Methods: this is a experimental study. We used isolated per fused rabbit AV-nodal preparation in two groups. In the first group, the control group, we studied the electrophysiological properties of AV-node. In the second group, the effect of cratagus hydroalcholic extract was tested in the presence of extract (0.1,1,3 mg/l) and repeat. we used 8 rabbits in two groups. Statistical analysis was performed by SPSS Mean wasused in the all results.
Result: our result showed non-significant increased in AV-nodal conduction time in all concentration of cratagus. Wenchebach prolonged at 3 mg/l of cratagus (157.1±3.4msec in control to165.7±3.4msec). rate dependent properties such as fatigue was increased by 3 mg/l of cratagus (13.2±1.8 msec in control to 20.8±3.1).
Conclusion: the above result indicated the differential effects of cratagus hydroalcholic extract on compact node. This search for the first time has explained the role of cratagus on the protective mechanism of artrioventricular node against supraventricular arrhythmia.

 
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