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Paper Information

Title: 

INVESTIGATING THE EFFECTS OF MC7 AND MC12, SELECTIVE PDE3 INHIBITORS, ON ISOLATED RAT ATRIA CONTRACTILE FORCE

Type: POSTER
Author(s): HOSSEINI A.*,SHAFIEINIK R.,PARSAEI H.
 
 *DEPT. OF PHARMACOLOGY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE, CENTRE OF MEDICINAL PLANT PHARMACOLOGY RESEARCH
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Selective PDE3 inhibitors, e.g. amrinone and milrinone, augment cardiac contractility force via increasing cAMP. mc7 and mc12 synthesized in Department of chemistry at Ferdosi university were shown to be PDE inhibitors and increase secretion of insulin. In this research we assessed the effect of these compounds on cardiac contraction force.
Method: Rats were anesthetized by thiopental. After isolating the heart, atrial was separated and transferred to a 50cc organbath. After stabilization of atria, different concentrations of isoprenaline, MC7 or MC12 alone and MC12 or MC7 plus isoprenaline, were added and the atrial contraction force (ACF) was recorded.
Results: Isoprenaline increased ACF with a dose-dependent manner (Maximum effect: 119.97+ 3.65%). Additin of 0.1Mm MC7 and MC12 increased ACF to 114.18+ 6.8 and115.3+ 2.14 respectively. In the presence of MC7 isoprenaline effect on ACF was amplified dose-dependently (Maximum effect: 142.01+5.96%). However, in the presence of MC12, at low concentrations, isoprenaline decreased ACF. But at higher concentrations, isoprenaline increased ACF (Maximum effect: 123.18+ 1.45%).
Conclusion: MC7, MC12 and isopernaline alone increased ACF. MC7 augemented the effect of isoprenaline on ACF. But Mc12 reversed the effects of lower concentrations. In addition to inhibition of PDE, MC12, In spite of structure similarity and also inhibitory effect on PDE by both compounds it seems that MC12 may induce other effects on atria which needs to be deeply explored.

 
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