Paper Information

Title: 

NORMOBARIC HYPEROXIA PRETREATMENT ATTENUATES ISCHEMIA-REPERFUSION (I/R) INDUCED INJURY IN ISOLATED RAT HEART

Type: POSTER
Author(s): POURKHALILI KH.*,HAJIZADEH S.,KHOUSHBATEN A.,ESMAEILI MANSOUR,HEYDARIANPOUR A.
 
 *PHYSIOLOGY DEPARTMENT, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Ischemia-reperfusion (I/R) injury is a major complication occurring in heart stroke, cardiopulmonary bypass surgeries and heart transplantation. The present study investigated whether normobaric hyperoxia elicits a preconditioning-like response and protects the heart from subsequent I/R injury. Male wistar rats were kept in normal air (21% O2) or in a hyperoxic (≥ 95% O2) environment for 60 minutes. Their hearts were isolated and langendorff perfused immediately or 24 hours afterward. Regional ischemia was induced for 30 minutes by occluding the left ascending coronary artery and then exposed to 120 minutes of reperfusion. Coronary flow was measured by timed collections of the coronary effluent during reperfusion. At the end of reperfusion, infarct size was determined by triphenyltetrazolium chloride staining. Results indicate that a preconditioning-like effect could be evoked by 60 minutes of hyperoxia, giving both immediate and delayed protection. Hyperoxia significantly reduced infarct size, and improved coronary flow. In conclusion, hyperoxia protects the isolated rat heart against ischemia-reperfusion injury and it can be used as a new preventive method for I/R injury in the heart.

 
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