Paper Information

Title: 

THE PROTECTIVE EFFECT OF NIGELLA SATIVA ALONE AND IN COMBINATION WITH DEXAMETHASONE ON TRACHEAL RESPONSIVENESS AND LUNG INFLAMMATION OF SULPHUR MUSTARD EXPOSED GUINEA PIGS

Type: SPEECH
Author(s): VAHEDI N.A.*,AMERI S.,BOSKABADI M.H.
 
 *DEPT. OF PHYSIOLOGY, MU MS, MASHHAD, I.R. IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The lung is one of the most exposable organs to chemical warfare agents such as sulfur mustard (SM) gas. In this study the effect of Nigella sativa (which has antiinflammatory effect) on tracheal responsiveness and lung inflammation of SM exposed animals was examined.
Methods: Guinea pigs were exposed to diluent's solution (control), 100 mg/m3 inhaled SM (SME), SME treated with Nigella sativa, 0.08 g daily (SME+N), dexamethasone, 5 mg/kg (SME+D) and both drugs (SME+N+D), and different measurements were done 14 days post-exposure (n=7 for each group). The weigh of animals were measured at the beginning, middle and at the end of the study.
Results: Tracheal responsiveness (TR) to methacholine of SME group were significantly higher than those of controls (p<0.001). The WBC in SME+N, SME+D and SME+ N +D was significantly greater than those of controls (p<0.01 to p<0.001). The TR in SME+N, SME+D and SME+ N +D was significantly lower compared to SME group (p<0.01 to p<0.001). also there was no any significant difference in TR and WBC between SME+D+ N, SME+ N  and SME+D groups. There was a weight loss in SME animals through the study but in the cases of  SME+D and SME+ N +D animals there was no any weight change. The eosinophil, monocyte and lympocytes in SME animals were significantly changed compared to control group (p<0.001 for all cases). There was an decreased of eosinophil in SME+D, and monocyte in SME+D+N, increased of basophil in SME+N and SME+N+D, increased of neutrophil in SME+D and its reduction in SME+N and SME+N+D groups compared to SME animals (p<0.05 to p<0.001).
Conclusion: These results showed a preventive effect of Nigella sativa, dexamethasone and their combination on TR of SME group.

 
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