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Paper Information

Title: 

COCAINE EXTRACTION, DETECTION AND QUANTIFICATION USING SPME-GC-MS-EI-SIM

Type: SPEECH
Author(s): MOSADEGH M.H.*,GHASEMI N.
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Cocaine is a drug involved in some poisoning episodes and fatalities. Solid Phase microextraction (SPME) is a new extraction technique, which uses a fused silica fiber coated with a polymeric coating to extract organic compounds from their matrices and directly transfer analytes into a gas chromatograph (GC) by thermal adsorption in a GC injector. This study reports for the first time, the development of a specific, sensitive and rapid procedure for identifying and quantifying of cocaine in postmortern matrices using direct immersion SPME and gas chromatography-mass spectrometry electron impact ionization selected ion monitoring (GC-MS-Ei-SIM). SPME conditions such as extraction temperature, extraction time, salt addition and PH were investigated and optimized. The most appropriated fiber coating for cocaine was found to be CW/DWB at PH 7. The calibration curve of the drug was reproducible and liner over the concentrations range of 1-7 mg/L.

 
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