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Paper Information

Title: 

CROSS SECTIONAL STUDY OF SERUM NITRITE AND NITRATE CONCENTRATION IN A NORMAL POPULATION

Type: SPEECH
Author(s): ZAHEDIASL S.,GHASEMI A.,SAADAT N.,AZIZI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Nitric oxide (NO) is an important signal and effecter molecule the activity of NO synthases can be altered by physical activity, nutrition, and body weight and also during certain pathological conditions. In this study, plasma concentrations of nitrite and nitrite (NOx) have been measured by the colorimetric method of Greiss. Intra and inter assay coefficient variations of the assay were less than 6% and the sensitivity was 2μmol/L. Fasting serum samples of 2889 healthy subjects, both genders (age 3-90) participating in the Tehran Lipid Glucose Study have been used to measure the metabolites concentrations. The results show that NOx concentrations increase with age in females but not in males. In the age group below 20 years the values in males and females were 29.2±0.7 and 27.1±0.6μmol/L respectively. Concentration in this age group of females was significantly lower compared to the age group of ≥60 (36.0±2.0). The results also indicated that there are significant correlations between serum NOx concentration with, WHR and diastolic pressure in males and BMI, WHR and systolic pressure in females. In conclusion it may be possible that by conducting a careful cross sectional study, NO metabolites measurement could serve as a tool for diagnosis and prognosis.

 
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