Paper Information

Title: 

EFFECTS OF INSULIN AND/OR ANTI-VENOM ON SOME BIOCHEMICAL PARAMETERS IN RABBITS ENVENOMED BY HEMISCORPIUS LEPTURUS SCORPION VENOM

Type: SPEECH
Author(s): RAAZI JALALI M.*,FATEMI TABATABAEI S.R.,AHMADIZADEH M.,GHODRATI M.
 
 *FAC. VET. MED., SHAHID CHAMRAN UNIVERSITY, AHVAZ
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Changes of CPK, LDH, glucose, electrolytes (Ca, Mg, Na and K) was studied after envenoming with H. lepturus scorpion and treated with insulin and / or antivenom. For this aim 36 rabbits were divided into four groups (A, B, C, and D) and each group to three sub groups then injected with (1, 2 and 3 μgr/gr, Sc). Groups B and C were injected with insulin (0.25 IU /kg, IM) and anti venom (2 ml/BW, IM) respectively. Group D was injected with both drugs 20 minute after envenoming. Blood samples were taken from jugular vein at the times 0 and 180 min. after envenoming to measure the levels of the biochemical parameters. Statistically significant elevation of CPK and LDH were seen in group A (P<0.05). Insulin could prevent the elevation of glucose and CPK in most insulin injected sub groups. The changes of K showed decrease in 180 min after envenoming in most sub groups of A and B groups (P<0.05). There was no significant change for other electrolytes. Thus, treatment with this drugs may prevent from some biochemical disorders in scorpion envenoming.

 
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