Paper Information

Title: 

AN INVESTIGATION OF THE LONG- TERM OF DIAZINON ON THE LEYDIG CELLS AND THE LEVELS OF TESTOSTERONE,LH AND FSH HORMONES IN MICE

Type: SPEECH
Author(s): JOURSARAEI S.GH.A.,FATHI E.A.,PARIVAR KAZEM,MOGHADAMNIA A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Diazinon (DZN) is an organophosphate pesticide in which could be resulted in damages of physiology and structural on reproductive system in animals. Therefore, in the present study, we investigated the long term effect of diazinon on Leydig cells of testis and levels of testosterone ,LH and FSH hormones in the mice.
Methods: For this experiment, the male mice divided into three groups. Mice in the experiment group were injected with consecutive dose of DZN (30mg/kg ip, five consecutive days per week for one month), Sham (water injection) and control (no injection). Animals were sacrified 35 after the latest injection. Blood samples were collected and testosterone, LH and FSH levels were assesed. Testis tissues sections were provided to investigate the changes of Leydig cells.
Result: The DZN showed a significant decrease in number of Leydig cells. subsequntly decreased serum testosterone level but increased the level of the FSH compared with control and sham groups while level of LH no significant increased.
Conclusion: According to the results, it could be suggested that the DZN can exert a significant toxic effects on testis of mice. on the other hand ,hormonal variations following DZN administration may be responsible for changes in infertility patern in the mice.

 
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