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Paper Information

Title: 

THE EFFECTS OF SULFUR MUSTARD ON GLUTATHIONE LEVEL AND ACTIVATION OF ANTIOXIDANT IN KIDNEY OF RATS

Type: SPEECH
Author(s): JAFARI M.,REZAEI R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Sulfur mustard (SM) is a potent alkylating agent that is a chemical warfare vesicant. It increases the formation of reactive oxygen species (ROS) such as superoxide anion and lipid peroxides. Reduced glutathione (GSH) is an important intracellular antioxidant that reacts with oxygen free radicals and acts as a substrate for other detoxification enzymes such as glutathione peroxidase (GPX) and glutathione S-transferase (GST). Glutathione reductase (GR) requires NADPH for its activity, resulting in the reduction of oxidized glutathione (GSSG) to GSH.
Methods In this study, Wistar rats (150-250 g body wt.) were randomly divided into nine groups as followed: group 1 control and group 2-9 experimental groups that received SM (1-80 mg/kg) by intraperitoneal injection only once. 6 rats in each group were killed after 1, 2, 7 and 14 days of exposure. The kidney of each groups were removed and the enzyme activities of GPX, GR and GST as well as GSH level were determined by biochemical methods.
Results: The results show that at concentrations lower than 20 mg/kg SM, the enhanced activity of GPX, GR and GST no change in GSH level were observed, but at concentrations higher than 20 mg/kg,  antioxidant enzyme activities were decreased as compared to the control group and the GSH level was significantly decreased.
Conclusion: At concentrations lower than 20 mg/kg, the enhanced activity of antioxidant enzymes no change in GSH level may be a compensatory response to scavenge reactive oxygen species generated by SM, while at higher of SM concentrations (20> mg/kg), SM induces oxidative stress response by depleting the antioxidant defense systems.

 
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