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Paper Information

Title: 

IMPORTANT IMPACT OF INOS ON THE EARLY RENAL HEMODYNAMIC AND TUBULAR RESPONSES TO ISCHEMIA/REPERFUSION INJURY IN ANAESTHETIZED RATS

Type: SPEECH
Author(s): SHAHED MOUSAVI S.M.*,GHOLAMPOUR F.,OUJI S.M.,HAJIZADEH S.
 
 *DEPT. OF PATHOLOGY AND PHYSIOLOGY, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: iNOS is the isoform of NO synthetases that is expressed during pathological condition such as cute renal failure. The aim of this study was to determine the role of iNOS on development of renal tissue damage and progression of renal functional disturbances over the post-ischemic immediate reperfusion period.
Methods: After preparing pentobarbital anaesthetized male Sprague-Dawley rats (290-340 g) for measuring renal functional variables, a 30-min control clearance period was taken. Following bilateral renal artery clamping for 30 min, four consecutive 30-min clearance periods during reperfusion were taken, and finally kidneys were removed. There were three groups (n=10), in which rats received (i.v.) L-NIL (3 mg/kg bolus, and then 1 mg/kg.h) as a selective iNOS inhibitor in I/R+N group from pre-ischemia, normal saline in I/R group, and normal saline without occlusion of renal arteries in sham group.
Results: The total renal histopathological score in I/R+N group (26.0
±2.0) was lower than that of I/R (61.0±0.4) group (P<0.05). During the last three 30-min of reperfusion with respect to the control period, renal ischemia caused progressive reductions in creatinine clearance (all P<0.001) that were markedly improved in group I/R+N, absolute potassium excretion (P<0.05-0.001) that were prevented in I/R+N group, urine osmolality and effective free water reabsorption (all P<0.001) that were ameliorated in I/R+N group; but elevations in fractional sodium excretion (all P<0.001) that were reduced in I/R+N group.
Conclusion: iNOS had a considerable role in the induction of renal tissue damages and the development of disorders in hemodynamics, excretory functions and urine concentrating ability during early phase of reperfusion following ischemia.

 
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