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Paper Information

Title: 

THE EFFECT OF NIFEDIPINE AND VERAPAMIL ON KIDNEY HISTOLOGY RAT

Type: SPEECH
Author(s): SHARIATI M.,POURSHAHNAZARI A.A.,ROUHBAKHSH A.,KHAKSARI M.,RAHMANI M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Diabetic nephropathy is one of the most problematic renal diseases because of the exponentially increasing number of patients chronic dialysis programs with renal failure resulting from diabetes. The aim of this study was the effect verapamil and nifidipine on diabetic kidney in rats.
Methods: In this experimental study 6 groups of rats were tested, group I) intact (sham) group II) diabetic (Control) III, IV) diabetic treated with verapamil or nifedepine V, VI normal rat which received verapamil or nifedipine diabetic rats were received 50 mg/kg streptozotosin (STZ). Verapamil was used 40mg/kg and nifedipine 10mg/kg/dl. the kidneys first weighted and then dissected for hydraxy prolyne evaluation and histological study. Sections stained by PAS ×H×E and three chrome masons methods. The diameters of Glomerulus's, proximal tubule, distal tubule and collecting ducts were measure in all groups.
Results: The mean of kidney weights have not shown significant change in all groups) in diabetic rats treated with verapamil (40 mg/kg/dl) and nifedipine (10mg/kg/dl). The diameter of glumerole , proximal tubule, distal tubule collection tubule have no significant change between normal and diabetic rats, but diameter of distal tubule and collecting tubules in normal animal were in created after receiving the verapamile and nifedipine (P<0.01), while in diabetic animals Jus increased the diameter of distal tubules (P<0.05). The pathological fixings were shown increase in basal membrane and member of collagen fiber in diabetic group.
Conclusion: it's conclude that verapamil and nifedipin could decreased interstitial fibrous tissue in all diabetic groups during this period. But for atrophy and another changer in kidney, longer period is needed.

 
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