Paper Information

Title: 

RELAXANT EFFECTS OF ROSA DAMASCENA ON GUINEA PIG TRACHEAL CHAINS AND ITS POSSIBLE MECHANISM (S)

Type: SPEECH
Author(s): KIANI S.*,BOSKABADI M.H.,RAKHSHANDEH H.
 
 *DEPT. OF PHYSIOLOGY, MUMS, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: rapeutic effects have been described for the flowers of Rosa damascena. Therefore in the present study.
Methods: The relaxant effects
of four cumulative concentrations of ethanolic extract (0.25, 0.5, 0.75, and 1.0 g%) and essential oils (0.25, 0.5, 0.75, and 1.0 volume%) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n=5) and 10 µM methacholine in two different conditions including: non-incubated tissues (group 2, n=8) and incubated tissues with 1 µM propranolol and 1 µM chlorpheniramine (group 3, n=4).
Results: 1 experiments two final concentrations of essential oil and theophylline and only final concentration of ethanolic extract showed relaxant effects compared to that of saline (p<0.01 to p<0.001). In group 2, three higher concentrations of ethanolic extract and theophylline and all concentrations of essential oil showed concentration dependent relaxant effects compared to that of saline (p<0.05 to p<0.001). In addition, the effect of 0.25 and 0.5 g% of essential oils in group 2 was significantly higher than those of theophylline and ethanolic extract (p<0.01 for all cases). In group 3 experiments the extract and essential oil of
Rosa damascena did not show any significant relaxant effect. There were significant correlations between the relaxant effects and concentrations for ethanolic extract and essential oil and theophylline in groups 1 and 2.
Conclusions: These results showed a potent relaxant effect of
Rosa damascena on tracheal chains of guinea pigs that was comparable to that of theophylline at concentrations used.

 
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