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Paper Information

Title: 

THE RELAXANT EFFECTS OF DIFFERENT FRACTIONS FROM NIGELLA SATIVA ON GUINEA PIG TRACHEAL CHAINS AND ITS POSSIBLE MECHANISM(S)

Type: SPEECH
Author(s): KEYHANMANESH R.*,BOSKABADI M.H.,EBRAHIMI SAADATLOU M.A.,KHAMENEHEI S.,MIRZAEI BAVIL F.
 
 *DEPT. OF PHYSIOLOGY, TUMS, TABRIZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Several therapeutic effects have been described for the flowers of Nigella sativa. In this study, the relaxant effects of n-hexane, dichloromethane, methanol and aqueous fractions of Nigella sativa on tracheal chains of guinea pigs were examined.
Methods: The relaxant effects of four cumulative concentrations of each fraction (0.8, 1.2, 1.6 and 2.0 g%) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.2, 0.4, 0.6 and 0.8 mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1) and 10 µM methacholine (group 2, n=6 for each group).
Results: In group 1, two last concentrations of n-hexane fraction and three last concentrations of dichloromethane and methanol fractions showed small but significant contractile effects compared to that of saline (p<0.05 to p<0.001)., All concentrations of theophylline in both groups and most concentrations of methanol, dichloromethane and n-hexane fractions in group 2 showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). The relaxant effect of most concentrations of all fractions were significantly less than those of theophylline in both groups (p<0.05 to p<0.001). The relaxant effect of most concentrations of methanol, dichloromethane fraction and n-hexane fraction were significantly greater in group 2 compared to group 1 (p<0.05 to p<0.001). There were significant positive correlations between the relaxant effects and concentrations for all fractions (except aquous fraction) in group 2 and for theophylline in both groups but a negative correlation for n-hexane, dichlormethan and methanol fractions in group 1 (p<0.05 to p<0.001).
Conclusions: These results showed a potent relaxant effect of different fractions from Nigella sativa (except aqueous fraction) on tracheal chains of guinea pigs. The most potent relaxant effect was seen for methanol and dichloromethane fractions.

 
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