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Paper Information

Title: 

ANTITUSSIVE EFFECT OF ASTRAGALUS GUMMIFER IN GUINEA PIGS

Type: SPEECH
Author(s): AFIAT M.*,BOSKABADI M.H.,RAKHSHANDEH H.,ALAMI Z.
 
 *DEPT. OF PHYSIOLOGY, GHAEM MEDICAL CENTRE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Several therapeutic effects including anti-asthma and dyspnoea have been described for Astragalus gummifer. In the present study the antitussive effect of this plant was evaluated.
Methods: The antitussive effects of aerosols of two different concentrations of macerated aqueous and ethanolic extracts, codeine, and saline were tested by counting the number of coughs produced due to aerosol of citric acid 10 min after exposing animal to aerosols of different solutions (n=8 for each solution).
Results: The results showed significant reduction of cough number observed in the presence of both concentrations of extracts and codeine (p<0.01 to p<0.001). The cough number observed in the presence of higher concentrations of macerated aqueous extract were significantly and that of ethanolic extracts nonsignificantly less than those of lower concentrations. In addition the effects of both concentrations of ethanolic extract were significantly greater than cough numbers observed in the presence of codeine. The antitussive effects of both concentrations of ethanolic extract were significant greater than cough numbers observed in the presence aqueous extrac (p<0.05 for both concentrations).
Conclusion: These results indicated potent antitussive effect of aqueous and ethanolic extract from Astragalus gummife which was greater than that of codeine for ethanolic extract.

 
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