Paper Information

Title: 

HISTOLOGICAL AND SECRETORY CHANGES OF RESPIRATORY EPITHELIUM TO THE INFLAMMATION- INDUCED BY CAPSAICIN IN BOTH RAT NASAL CAVITIES

Type: SPEECH
Author(s): BAKHSHESH M.,HEYDARIAN ESFANDIAR
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: It seems that inflammation of different parts of the respiratory system could affect the other parts of the airways. Luckotriens are the most important mediators of inflammatory cells and their possible contribution in nasobronchial inflammatory reflexes has been reported. Therefore, in the present study we tried to assess their possible role in upper and lower airways inflammation and respiratory disorders.
Material and methods: Severity of inflammation was measured 6 and 24 hours after insertion of micropads- moistured with saline or 50 & 100μgr Capsaicin into middle nasal turbinate. For assessment of inflammation and its mechanism, intraperitoneal injection of 2 & 5 mg/kg Monteluckast (as common Luckotrien receptor antagonist) were administered.
Results: Saline-moistured micropads caused significant increase in mucus secretion and mucosal eosinophils count in chronic phase, only (P<0.05). Different doses of capsaicin- caused dose-dependent increase in inflammation in both phases, however this response more significantly observed in right nasal cavity (P<0.001). Intraperitoneal injection of different doses of Monteluckast in 2 & 5 mg/kg dose dependently, caused significant decrease in capsaicin- induced inflammation, This effect was observed with more decrease in left nasal cavity (P<0.05).
Conclusion: It is concluded that the Luckotriens have potential role in pathogenesis of upper air ways- mediated inflammation of respiratory disorders and that different results with left & right nasal cavities might be due to different innervation of these cavities.

 
Keyword(s): 
 
Yearly Visit 10   tarjomyar
 
Latest on Blog
Enter SID Blog