Paper Information

Title: 

EFFECTS OF CIMETIDINE ON MALE REPRODUCTIVE SYSTEM

Type: SPEECH
Author(s): TAKZARE A.R.,TAKZARE N.,LASHKARI M.H.,YARMOHAMMADY K.,EHTESHAMI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

In the present study the effect of cimetidine on male Reproductive system and sperm motility was studied. 60 mature male rats weighed 250-300gr were divided in 3 groups: Control group, received normal saline and test I group received cimetidine 100 mg/kg/day for one week. Test II group received cimetidine 100mg/kg/day for five weeks. The result revealed that sperm count was decreased in the test groups compared to control group and non motile sperms were increased in test compared to control group. The data were analysed using t-test and P value < 0.05 showed significant decrease in sperm counts of test group rats. Then the testises were excised from body and after weighing we studied them microscopically. Results revealed lower testicular weights in test II group. Atrophy of spermatic germ cells and hypoplasia of spermatic germinal layer of seminiferous tubules were observed microscopically. We concluded that the above changes may be due to the direct effect of cimetidine on the seminiferous tubules which is reversible.

 
Keyword(s): CIMETIDINE, MALE REPRODUCTIVE SYSTEM, SPERM
 
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