Paper Information

Title: 

THE EFFECTS OF AQUEOUS EXTRACT FROM TEUCRIUM POLIUM L. ON RAT GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL-STIMULATED CONDITIONS

Type: PAPER
Author(s): NIAZMAND S.,HAJZADEH M.A.R.,KESHAVARZI Z.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

BACKGROUND: Several reports have demonstrated antidiabetic, Lipid lowering and antibacterial properties of Teucrium polium L. but its effects on gastric acid secretion had not been studied. The aim of this study is investigating the effects of aqueous extract from Teucrium polium L. on rat gastric acid secretion in basal, vagotomized and vagal-stimulatated conditions.
METHODS: 24 Wistar rats were randomly divided in two groups of case and control. Animals were anesthetized by sodium thiopental. Gastric secretion were collected by wash out technique for 15 min. Aqueous extract of the plant were prepared by maceration and 1ml of three doses of 20, 40 and 80 mg/kg were introduced into the stomach of each rat in case group and the same volume of saline in control group. Two samples of gastric secretion for 15 min were collected for each condition and then total titrable acid was measured by titrator. The results were analyzed by t-test, p<0.05 were considered to be significant.
Results: The difference between first and second samples in case group were significant (p<0.05) only in vagotomized condition. The acid secretion in vagotomized VS basal condition and in vagotomized VS vagal-stimulated condition were significant (p<0.05). The acid secretion in basal condition was significantly decreased by 5 mg/ml of extract (p<0.05), while in vagotomised condition the acid secretion was decreased for both 5 and 10 mg/ml concentration of the extract VS saline (p<0.05) the difference of acid secretion in case group compared to control group was not significant in three conditions.
CONCLUSION: We found no significant difference in acid secretion with 3 different concentrations of aqueous extract from Teucrium polium between control and case groups in three conditions.

 
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