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Paper Information

Title: 

EFFECT OF STZ-INDUCED DIABETES ON GASTRIC MOTILITY RAT (IN VIVO STUDY)

Type: PAPER
Author(s): NABAVIZADEH F.*,ADELI S.
 
 *DEPARTMENT OF PHYSIOLOGY, TEHRAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

More than 50% of diabetic patients have abdominal pain, nausea and bloating. Gastric emptying is delayed in diabetic patients. It has not recorded any study about gastric motility (gastric pressure) in diabetics. So our goal of this research is to assess the effects of STZ induced-diabetes on basal and stimulated by Ach on gastric motility in rats. We used 250-350gr weighted male Wistar rats. We administrated STZ 45mg/kg, ip in diabetic group, vehicle group received normal saline and control group received nothing. We collected sample blood every week for five weeks and blood sugar was measured. A diabetes criterion was blood sugar more than 300mg/dl. In day 35 animals were anesthetized by sodium thiopental (50mg/kg, ip). After tracheostomy and laparatomy a silicon tube with a balloon was inserted in stomach via duodenum. This tube was connected to a pressure transducer which was attached to a physiograph. Gastric pressure was recorded in different situations. Basal gastric pressure for control, vehicle and diabetic groups were 14±1.4, 15.9±1.56 and 13.7±0.86mmHg, respectively. Ach-stimulated gastric pressure for control, vehicle and diabetic groups were 28.3±1.77, 30.8±2.03 and 30.6±0.05mmHg, respectively. There were no significant differences in the basal and stimulated gastric pressure between all of the three groups. But Ach-stimulated gastric pressure was more than basal state in every group. Therefore, STZ-induced diabetes has no effect on gastric motility. Although in previous study diabetes could change gastric secretion even in shorter period. It is probable the sensitivity of secretary cells is more than muscular cells in response to diabetes.

 
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