Paper Information

Title: 

EFFECT OF ESOPHAGEAL DISTENTION ON BASAL AND STIMULATED GASTRIC ACID SECRETION IN RATS

Type: SPEECH
Author(s): MARD S.A.*,GHARIB NASERI MOHAMMAD KAZEM
 
 *AHWAZ JUNDI SHAPOUR OF MEDICAL SCIENCES, THE MEDICAL SCHOOL, DEPT OF PHYSIOLOGY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion.
Methods: Adult male Wistar rats (200-240g) were deprived of food but not the water 24 h before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated.
Results: Basal and gastric distention, carbachol- and histamine-stimulated acid secretion were reduced by the esophageal distention (P<0.05, P<0.0001, P<0.01 and P<0.02, respectively). L-NAME (10 mg/kg, i.v.) elevated the acid output (P<0.002). Vagotomy reduced the inhibitory effect of the esophagus distention on gastric distention-induced acid secretion (P<0.01).
Conclusion: These results indicate that the vagus nerves are involved in the inhibitory effect of the esophageal distention on the basal and stimulated gastric acid secretion. Furthermore, nitric oxide (NO) could be involved.

 
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