Paper Information

Title: 

THE EFFECTS OF TACHYKININ RECEPTORS ANTAGONISTS ON RELAXATION AND CONTRACTILE RESPONSES INDUCED BY ELECTRICAL STIMULATION IN DIFFERENT REGIONS OF THE RAT SMALL INTESTINE

Type: PAPER
Author(s): FARAJIAN MASHHADI F.*,NAYLOR R.,JAVID F.
 
 *SCHOOL OF PHARMACY UNIVERSITY OF BRADFORD
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The distribution of tachykinin receptor subtypes and their role in the control of motility of the mammalian gastrointestinal tract is variable, depending on the species and regions of the gut (Vannucchi et al., 2000). Although many investigations have been carried out about tachykinin receptors in gastrointestinal tract, there are still discrepant results reported about the location and function of tachykinin receptors (Hozler-Petsche, 1995). In the present study the in vitro topographical studies were carried out to investigate the tachykinins involved in contraction and relaxation responses by applying electrical field stimulation (EFS) using different frequencies of stimulation in different regions of the rat small intestine. The NK1 receptor antagonist, L-732,138 and NK3 receptor antagonist, SB218795 failed to modify concentration response curve to exogenously added substance P (SP) and neurokinin B (NKB) respectively. However MDL29, 913, a NK2 receptor antagonist was able to significantly shift the concentration response curve to exogenously added NKA (NK2 receptor agonist) to the right. None of the tachykinins antagonists used in this stuy was able to modulate consistently or significantly the EFS-induced relaxation and contraction responses in normal or non-adrenergic non-cholinergic (NANC) conditions. However all antagonist used  were able to modify the contractile response to exogenous agonists in electrically stimulated tissues, depending on the frequency applied and region of the rat small intestine. This study demonstrate the presence of three endogenous tachykinins and the key role of tachykinin2 receptors in different regions of the rat small intestine.

 
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