Paper Information

Title: 

DOES CIRRHOSIS AFFECT THE NONADRENERGIC NONCHOLINERGIC-MEDIATED RELAXATION OF CORPUS CAVERNOSUM

Type: SPEECH
Author(s): SADEGHIPOUR HAMED*,GHASEMI MAHDI,MANI A.R.,DEHPOUR AHMAD R.
 
 *DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES (TUMS), IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Cirrhotic condition can cause hemodynamic abnormalities in many organ systems. Nitric oxide (NO) overproduction due to increased NO synthase (NOS) activity play a major role in developing these complications. Since NO, synthesized by NOS in nonadrenergic noncholinergic (NANC) nerves within corpus cavernosum, plays a crucial role in relaxing the cavernosal tissue and thereby inducing erection, in the present study by using the rat model of cirrhosis we examined whether the NANC-mediated relaxation of corpus cavrenosum is affected by cirrhosis.
Methods: Corporal tissues of control and cirrhotic (4 weeks after bile duct ligation) rats were isolated for evaluation of relaxant responses to electrical field stimulation (EFS) in organ bath. The relaxations in the presence of nonselective and selective neuronal NOS inhibitors (L-NAME and L-NPA, respectively) in both groups were also evaluated. Moreover, the relaxant responses to sodium nitroprusside (NO donor) were evaluated in both groups.
Results: EFS-induced relaxations were significantly (P<0.001) more potent in cirrhotic group. Both L-NAME (0.03-10µM) and L-NPA (0.1-10 µM) significantly (P<0.001) decreased the relaxation in a dose-dependent manner, but cirrhotic groups were more resistant to these inhibitory effects. However, relaxations induced by sodium nitroprusside were similar in these two groups. Discussion: Our results for the first time demonstrated that cirrhosis causes enhancement of the neurogenic relaxation of rat corpus cavernosum. This effect can be due to the increased neuronal NOS activity in cavernosal nerves and thus NO overproduction.

 
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