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Paper Information

Title: 

COMPARISON BETWEEN THE EFFECTS OF ETOMOXIR AND RANOLAZINE ON INFARCT SIZE IN THE ISCHEMIC HEART

Type: SPEECH
Author(s): NAJAFI M.,ETERAF OSKOUEI T.,GARJANI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: To date, there is not reported any comparative study between the effects of Etomoxir and Ranolazine on ischemia/reperfusion injuries (esp. infarct size), so that their effects on infarct size in the ischemic isolated rat heart were studied and compared.
Methods: Isolated rat hearts were divided into 3 groups randomly (n=6 in each group) and mounted on a non-recirculating Langendorff apparatus at constant pressure. In control group, the hearts were perfused by a modified Krebs-Henseleit solution at stabilization, 30min regional ischemia and 120min reperfusion while in the test groups; they were perfused by enriched Krebs solution with 1µM of Etomoxir or 20µM of Ranolazine during ischemia/reperfusion. At the end of reperfusion, Evans Blue solution was infused to stain the non-ischemic area. Then the heart was cut into slices and incubated by 1% TTZ solution and fixed in formalin. The area of infracted tissue and area at risk were determined by a computerized planimetry. Results: In the control group, infarct size was 46.3±2.9%, while Etomoxir reduced infarct size  to 20.9±5%
(P>0.01) Perfusion of the hearts by Ranolazine enriched Krebs solution produced greater reduction in infarct size (0.001>p, %3.6±16.4) The effect was not statistically significant between the test groups. Conclusion: It seems that Etomoxir (a fatty acid uptake inhibitor) and Ranolazine (a fatty acid oxidation inhibitor) likely by indirect increasing of glucose oxidation may improve reperfusion recovery of ischemic heart and reduce infarct size. The results showed protective effects of Etomoxir and Ranolazine on infarct size without any significant difference between the agents.

 
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