Paper Information

Title: 

NEUROPEPTIDES: CONTROL OF HORMONE SECRETION, APPETITE, AROUSAL AND PAIN

Type: SPEECH
Author(s): TAKAHASHI K.*
 
 *TOHOKU UNIVERSITY SCHOOL OF HEALTH SCIENCES, SENDAI 980-8575, JAPAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Neuropeptides include a broad rage of peptides with various biological functions. For example, hypothalamic hormones, such as corticotropin releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH), regulate the secretion of anterior pituitary hormones. In addition, certain neuropeptides in the hypothalamus regulate the appetite. Neuropeptides Y (NPY), melanin-concentrating hormone (MCH), and orexin-A stimulate appetite, whereas a-melanocyte stimulating hormone (aMSH) and CRH suppress the appetite. Actually, one neuropeptide plays multiple roles in the brain, and interacts with classical neurotransmitters, such as catecholamines and histamine. For example, orexin-A stimulates the arousal and interacts with histamine. The dysfunction in the orexin-A function results in a sleep disorder, narcolepsy. Furthermore, central administration of orexins enhanced anti-nociception in mice. This anti-nociceptive effect was further enhanced in histamine H1 or H2 receptor gene knockout mice. Therefore, orexin-A is related not only to the appetite control, but also to the arousal and pain control, possibly via the interaction with histamine. I would like to summarize the research in neuropeptides focusing on their multiple functions in the brain.

 
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