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Paper Information

Title: 

POSTNATAL CHANGES OF NADPH-DIAPHORASE REACTIVITY IN THE SPINAL CORD OF CONGENITAL HYPOTHYROID WEANED PUPS

Type: SPEECH
Author(s): AKBARI Z.*,BEHZADI G.
 
 *NEUROSCIENCE RESEARCH CENTER AND PHYSIOLOGY DEPT, FACULTY OF MEDICINE, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: NOS containing neurons are largely distributed in the dorsal horn and lamina X of the spinal cord. Recently an important function for NO in transmission of pain signal and synaptic plasticity at nociceptive spinal synapses has been suggested. Synaptic plasticity plays a key role in the structural and functional development of the nervous system. On the other hand thyroid hormones are critical for maturation of nervous system. Here we aimed to investigate the effect of congenital hypothyroidism on the nNOS containing neurons in spinal dorsal horn by NADPH-d histochemistry.
Methods: 21 days old rat pups were divided in two groups: normal and PTU-induced congenital hypothyroid. The pups were anesthetized and were perfused with fixative. Coronal frozen sections were obtained from spinal cord L4-L6. Sections were processed for NADPH-d reaction. Stained neurons in superficial dorsal horn and around central canal were counted and on the basis of their staining intensity were classified into Heavy (H) and Light (L) groups.
Results: Significant increases in the number of both groups of NADPH-d+ neurons (H & L) in superficial dorsal horn (P<0.005) and lamina X (P<0.001) in hypothyroid pups in compare to control animals were observed. In addition morphological changes of NADPH-d+ neurons in hypothyroid rats were of our interest.
Conclusion: The increased number of NADPH-d+ neurons in the congenital hypothyroid pups may be related to the changes in pain circuit at spinal cord level.

 
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