Paper Information

Title: 

THE STUDY OF ANTI- NOCICEPTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF LIPPIA CITRIODORA KUNTH IN RAT USING FORMALIN TEST

Type: PAPER
Author(s): ARZI A.,AGHEL N.,GOUDARZI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

In traditional medicine some plants have analgesic effect .this study was undertaken to determine the effect of hydroalcoholic extract of Lippia citriodora kunth on formalin induced early and late phase pain in rats .in this study ,the anti-nociceptive effect of different doses (200, 400, 600 and 800 mg/kg IP) of Lippia citriodora kunth extract were investigated using formalin test .according to the results ,all of the doses of extract had anti-nociceptive effect in all of study times, except at 0-5 min of experiment. the highest anti-nociceptive effect was found in dose of 600 mg/kg. considering the result, it was found that the anti-nociceptive effect of extract (600 mg/kg) was comparable to morphine (2.5 mg/kg) and aspirin (300 mg/kg). it is also demonstrated that the extract just like aspirin, inhibits the second phase of pain, and its mechanism of action is probably through inhibition of the inflammation by it is peripherally effect.

 
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