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Paper Information

Title: 

BLOCKADE OF N-METHYL-D-ASPARTATE (NMDA) RECEPTORS IN THE VENTRAL TEGMENTAL AREA PREVENTS IMPROVING EFFECT OF NICOTINE ON MORPHINE STATE-DEPENDENCY IN RAT

Type: SPEECH
Author(s): AHMADI SH.A.D.,ZARINDAST M.R.,HAERI ROUHANI ALI,REZAEI AMENEH
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The interaction of opiate, cholinergic, glutamatergic and (possibly) dopaminergic inputs in the ventral tegmental area (VTA) to influence a learned behavior is certainly a topic of great interest. In the present study, the effect of N-methyl-D-aspartate (NMDA) receptors in the VTA in nicotine's effect on improvement of state-dependent memory of morphine was investigated.
Methods: A step-through inhibitory avoidance (IA) task was used for memory assessment in male Wistar rats.
Results: Subcutaneous (s.c.) administration of morphine (5 and 7.5 mg/kg) after training impaired IA memory. Pre-test administration of the same doses of morphine and nicotine (0.2, 0.4 and 0.6 mg/kg, s.c.), 30 min before the test, reversed the memory impairment. Blockade of NMDA receptors by intra-VTA administration of their competitive antagonist, D-AP5 (0.25, 0.5, 1 and 2 µg/rat) alone had no effect on memory impairment induced by morphine. On the other hand, intra-VTA administration of D-AP5 (0.5, 1 and 2 µg/rat) in combination with an effective dose of nicotine (0.4 mg/kg, s.c.) prevented the improving effect of nicotine on state-dependent memory of morphine.
Conclusions: It can be concluded that NMDA receptors in the VTA
may modulate the effect of nicotine on memory.

 
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