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Paper Information

Title: 

INTRAHIPPOCAMPAL INFUSION OF LIPOPOLYSACCHARIDE INHIBITS AMYGDALA-KINDLED SEIZURES IN RATS BY ELEVATION OF NITRIC OXIDE LEVEL

Type: SPEECH
Author(s): AHMADI A.,SAYAH M.,NAHRAVANIAN H.,HAERI ROUHANI SEYED ALI
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Central nervous system inflammation in cases such as head trauma, stroke and infection has been associated with the occurrence of epileptic seizures. Microglias, the principle immune cells in the brain readily become activated in response to injury, infection or inflammation. The bacterial endotoxine lipopolysaccharide (LPS) induces the activation of microglia and the production of proinflammatory factors including nitric oxide (NO) and prostaglandins. We studied the effect of intrahippocampal administration of LPS on kindled-seizures in rats.
Methods: the rats were kindled by daily electrical stimulation of basolateral amygdala. The kindled rats were received different doses of LPS intrahippocampally. The seizure parameters and the hippocampal NO level were then measured in the animals.
Results: LPS at the dose of 5µg/rat significantly decreased duration of generalized seizures and related afterdischarges at 0.5 h and 3 h after administration. The level of NO increased 0.5 h after LPS administration into the hippocampus.
Conclusion: LPS inhibits amygdala-kindled seizures in rats and NO may partly be involved in this effect.

 
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