Paper Information

Title: 

PARKINSON'S DISEASE: SEVEN WORKS ON ANIMAL MODELS DURING LAST FIVE YEARS IN AHWAZ-IRAN

Type: PAPER
Author(s): SARKAKI A.R.*,FARZI A.,BADAVI M.,AMANI R.
 
 *PHYSIOLOGY RESEARCH CENTER, AHWAZ JONDISHAPOUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The Primary cause of PD is degeneration of dopaminergic neurons in nigrostriatal system, which results in a dramatic decrease in dopamine content in the corpus striatum. The hallmark of PD is progressively impaired control of movement, alteration of autonomic function, cognition, behavior and dementia. Done projects contain:
1. Effect of oral administration of sesame oil on PD.
2. Effect of NMDA receptor selective antagonist (AP-5) on PD.
3. Effect of non-NMDA receptor antagonist (AMPA) on PD.
4. Effect of systemic administration of Vit. E on PD related motor disorders and striatal Ach.
5. Effect of peripheral and central administration of estrogen on PD in OVX rats.
6. Effect of NMDA receptor nonselective antagonist (MK-801) on PD.
7. Effect of oral administration of soy on PD in OVX rats.
Our findings showed that:
1. Sesame oil (10% of diet) had beneficial effect on PD related motor disorders and brain local EEG.
2. NMDA receptor selective antagonist (AP-5) did not affect on PD related motor disorders and brain local EEG.
3. Both AMPA receptor antagonist (AMPA) and non-selective NMDA receptor antagonist (MK-801) had beneficial effects on PD related motor disorders and brain local EEG.
4. Systemic administration of Vit. E had beneficial effects on PD related motor disorders and striatal Ach.
5. Estrogen may protect the nigro-striatal dopaminergic pathway from degeneration and delay the onset both PD and PD- related dementia. However, estrogen has proliferative and oncogenic effects on non- neural cells which are responsive to estrogen, such as breast and endometrium cells. Plant-derived non-steroidal estrogens found in high abundance in most soy food products, may contain beneficial effects of estrogen without its unwanted side effects.

 
Keyword(s): 
 
Yearly Visit 16   tarjomyar
 
Latest on Blog
Enter SID Blog