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Paper Information

Title: 

SPREADING DEPRESSION RELATED DISORDERS

Type: PAPER
Author(s): GORJI ALI*
 
 *INSTITUTE OF PHYSIOLOGY I, MUNSTER, GERMANY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Spreading depression (SD), a transient reversible phenomenon with characteristic ionic, metabolic and hemodynamic changes, has been known for over 60 years. A vast number of studies into this mysterious experimental event provide evidence for SD involvement in brain pathophysiology. There is sufficient evidence to admit that SD plays an important role in some clinical disorders including migraine with aura, cerebrovascular diseases, head injury spinal cord disorders, epilepsy, and transient global amnesia. Although the occurrence of SD in aura phase of migraine as well as in brain hemorrhage is demonstrated, the role of SD in other diseases needs to be elucidated. Learning more about the importance of SD may increase our understanding of SD associated disorders and improve our fundamental research strategies.

 
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